Kylian Mbappe has been ruled out of Paris Saint-Germain's clash with Lille due to an ear infection while Lionel Messi is doubtful with a knock, as summer signing Sergio Ramos nears a return to full training.
Ligue 1 leaders PSG are due to take on the reigning champions at Parc des Princes on Friday night, with 13 points currently separating the sides in the table.
Mauricio Pochettino's team will be aiming to bounce back from a disappointing 0-0 draw with Marseille, but their preparations have been hampered by the loss of top scorer Mbappe.
The French forward, who has six goals from 14 outings across all competitions so far this season, has been sidelined through illness and won't join up with the squad until next week.
A statement on PSG's website read: "Kylian Mbappe is continuing his treatment for his infection and will resume training early next week."
